The concept of Evidence-Based Toxicology
نویسندگان
چکیده
Evidence-based-medicine (EBM) has been a revolution in clinical medicine over the last three decades, showing the advantage of objective, critical and systematic reviews of current practices as well as formal meta-analysis of data and central deposits of current best evidence for a given medical problem. Toxicology might benefit from a similar rigorous review of traditional approaches and the development of meta-analysis tools as well a central quality-controlled information portal. Already in 1993 Neugebauer and Holaday in their book “Handbook of mediators of septic shock” showed that EBM methods can be applied to animal studies and in vitro work. With Sebastian Hoffmann and his thesis “Evidence-based in vitro toxicology” in 2005 we developed initial concepts of an evidence-based toxicology (EBT).
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